(?)-CR-1-31-B

Base Information

• Chemical Name: (?)-CR-1-31-B
• CAS No.: 1352914-52-3
• Molecular Formula: C₂₈H₂₉NO₈
• Molecular Weight: 507.54
• Mol file: 1352914-52-3.mol

Synonyms:(?)-CR-1-31-B

Chemical Property of (?)-CR-1-31-B

Chemical Property:

Purity/Quality:

99%,98%, ^*data from raw suppliers

CR-1-31-B 98.06% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (?)-CR-1-31-B

There total 4 articles about (?)-CR-1-31-B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N-methoxylamine hydrochloride (593-56-6) + endo rocaglic acid (190385-15-0) → (?)-CR-1-31-B (1352914-52-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm201263k

Reference yield:

(-)-rocaglaic acid-(L)-menthyl ester → (?)-CR-1-31-B (1352914-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydroxide / dimethyl sulfoxide / 3 h / 60 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm201263k

Reference yield:

rac-(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxylic acid → (?)-CR-1-31-B (1352914-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: water; sodium hydroxide / dimethyl sulfoxide / 3 h / 60 °C / Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm201263k

upstream raw materials:

N-methoxylamine hydrochloride

endo rocaglic acid

Refernces