Cbz-HN-Ala-Ala

Base Information

• Chemical Name: Cbz-HN-Ala-Ala
• CAS No.: 22221-70-1
• Molecular Formula: C₁₄H₁₈N₂O₅
• Molecular Weight: 294.307
• Mol file: 22221-70-1.mol

Synonyms:Cbz-HN-Ala-Ala

Chemical Property of Cbz-HN-Ala-Ala

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-HN-Ala-Ala

There total 8 articles about Cbz-HN-Ala-Ala which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonylalanine (4132-86-9,26607-51-2,1142-20-7) + 3-ethoxy-3-diethoxyphosphoryloxy-acrylic acid ethyl ester (5487-69-4) → Cbz-HN-Ala-Ala (22221-70-1)

Guidance literature:

With acetone; at 70 ℃; Behandeln des Reaktionsgemisches mit DL-Alanin und wss. NaOH unter Zusatz von Benzol;

DOI:10.1017/S0003598X00089973

Reference yield:

DL-α-alanylalanine (1115-78-2,1948-31-8,2867-20-1,3695-80-5,56271-29-5,59247-16-4,90580-65-7,90760-70-6,99265-26-6,923-16-0,110652-05-6,210687-33-5,2392-61-2) + benzyl chloroformate (501-53-1,94274-21-2) → Cbz-HN-Ala-Ala (22221-70-1)

Guidance literature:

With sodium hydroxide; unter Kuehlung erhalten, Zerlegung durch fraktionierte Krystallisation aus Wasser und aus Aethylacetat in Praeparate von unterschiedlichem Schmelzpunkt;

Reference yield:

N-benzyloxycarbonylalanine (4132-86-9,26607-51-2,1142-20-7) → Cbz-HN-Ala-Ala (22221-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) ClCO₂Et, Et₃N, (ii) /BRN= 3619264/, Et₃N

2: aq. NaOH

With sodium hydroxide;

upstream raw materials:

N-benzyloxycarbonylalanine

3-ethoxy-3-diethoxyphosphoryloxy-acrylic acid ethyl ester

DL-α-alanylalanine

benzyl chloroformate