Technology Process of 3-bromo-2-ethoxy-5-phenylthiophene
There total 2 articles about 3-bromo-2-ethoxy-5-phenylthiophene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,5-dibromo-2-ethoxythiophene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
for 1h;
With
boric acid tributyl ester;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1.5h;
iodobenzene;
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
tetrahydrofuran; hexane; water;
at 70 ℃;
Further stages.;
DOI:10.1021/jo020114o
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 94 percent / N-bromosuccinimide / CH2Cl2 / 20 °C
2.1: n-BuLi / hexane; tetrahydrofuran / 1 h
2.2: tri-n-butyl borate / tetrahydrofuran; hexane / 1.5 h / -78 °C
2.3: 76 percent / Na2CO3; tetrakis(triphenylphosphine)palladium / tetrahydrofuran; hexane; H2O / 70 °C
With
N-Bromosuccinimide; n-butyllithium;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo020114o
- Guidance literature:
-
3-bromo-2-ethoxy-5-phenylthiophene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1.5h;
octaperfluorocyclopentene;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 3h;
Further stages.;
DOI:10.1021/jo020114o
