2-cyclohexylthiazole

Base Information

• Chemical Name: 2-cyclohexylthiazole
• CAS No.: 25039-86-5
• Molecular Formula: C₉H₁₃NS
• Molecular Weight: 167.275
• Mol file: 25039-86-5.mol

Synonyms:2-cyclohexylthiazole

Chemical Property of 2-cyclohexylthiazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-cyclohexylthiazole

There total 4 articles about 2-cyclohexylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1,3-thiazole (288-47-1) + Cyclohexanecarboxylic acid (98-89-5) → 2-cyclohexylthiazole (25039-86-5)

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In dichloromethane; water; at 20 ℃; for 8h;

DOI:10.1039/c3cc48069k

Reference yield: 75.0%

2-chloroethanal (107-20-0) + cyclohexanecarbothioamide (7390-42-3) → 2-cyclohexylthiazole (25039-86-5)

Guidance literature:

With acetic acid; In acetone; at 50 ℃; for 14h;

Reference yield:

cyclohexylcarboxamide (1122-56-1) → 2-cyclohexylthiazole (25039-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Lawessons reagent / tetrahydrofuran / 14 h / 50 °C / Inert atmosphere

2: acetic acid / acetone / 14 h / 50 °C

With Lawessons reagent; acetic acid; In tetrahydrofuran; acetone;

upstream raw materials:

cyclohexylcarboxamide

1,3-thiazole

Cyclohexanecarboxylic acid

2-chloroethanal

Refernces

• 1、 Zhao, Wei-Ming,Chen, Xiao-Lan,Yuan, Jin-Wei,Qu, Ling-Bo,Duan, Li-Kun,Zhao, Yu-Fen. "Silver catalyzed decarboxylative direct C2-alkylation of benzothiazoles with carboxylic acids". supporting information. p. 2018 - 2020. Retrieved 2014/03/21.