1,5-Diethyl-2,4-dimethoxybenzene

Base Information

• Chemical Name: 1,5-Diethyl-2,4-dimethoxybenzene
• CAS No.: 52959-34-9
• Molecular Formula: C₁₂H₁₈O₂
• Molecular Weight: 194.274
• DSSTox Substance ID: DTXSID301302292
• Nikkaji Number: J2.511.487F
• Mol file: 52959-34-9.mol

Synonyms:1,5-Diethyl-2,4-dimethoxybenzene;52959-34-9;SCHEMBL11955598;DTXSID301302292

Chemical Property of 1,5-Diethyl-2,4-dimethoxybenzene

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 194.130679813
• Heavy Atom Count: 14
• Complexity: 142

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=CC(=C(C=C1OC)OC)CC

Technology Process of 1,5-Diethyl-2,4-dimethoxybenzene

There total 3 articles about 1,5-Diethyl-2,4-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethyl-2,4-dimethoxybenzene (19672-03-8) → 2,4-diethyl-1,5-dimethoxybenzene (52959-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / AlCl₃ / CH₂Cl₂ / 2 h / 0 °C

2: 75 percent / H₂, conc. aq. HCl / 10percent Pd/C / ethanol / 4.5 h / 760 Torr / Ambient temperature

With hydrogenchloride; aluminium trichloride; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00151a010

Reference yield:

1,1'-(4,6-dimethoxy-1,3-phenylene)diethanone (3098-67-7) → 2,4-diethyl-1,5-dimethoxybenzene (52959-34-9)

Guidance literature:

With hydrogenchloride; zinc; In benzene; Heating;

Reference yield:

1-(5-acetyl-2,4-dihydroxyphenyl)-1-ethanone (2161-85-5) → 2,4-diethyl-1,5-dimethoxybenzene (52959-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone

2: Zn, aq. HCl / benzene / Heating

With hydrogenchloride; potassium carbonate; zinc; In acetone; benzene;

upstream raw materials:

1,1'-(4,6-dimethoxy-1,3-phenylene)diethanone

1-ethyl-2,4-dimethoxybenzene

1-(5-acetyl-2,4-dihydroxyphenyl)-1-ethanone

Downstream raw materials:

2,6-dimethoxy-3,5-diethylbenzoic acid

Refernces