Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl

Base Information

• Chemical Name: Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl
• CAS No.: 1401720-10-2
• Molecular Formula: C₃₇H₄₁N₃O₇
• Molecular Weight: 639.748
• Mol file: 1401720-10-2.mol

Synonyms:Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl

Chemical Property of Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl

There total 4 articles about Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

H-D-Trp-O-cyclohexyl hydrochloride + 1-benzyl N-carbobenzoxy-L-glutamate (65706-99-2) → Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl (1401720-10-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; at 20 ℃; Inert atmosphere;

Reference yield:

cyclohexanol (108-93-0) → Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl (1401720-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 96 h / 20 °C

2: hydrogenchloride / dichloromethane / 0.5 h / 5 - 10 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

Boc-D-Trp-OH (5241-64-5) → Cbz-D-Glu(D-Trp-O-cyclohexyl)-O-Bzl (1401720-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 96 h / 20 °C

2: hydrogenchloride / dichloromethane / 0.5 h / 5 - 10 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

upstream raw materials:

cyclohexanol

Boc-D-Trp-OH

1-benzyl N-carbobenzoxy-L-glutamate

Boc-D-Trp-O-cyclohexyl

Downstream raw materials:

H-D-Glu(D-Trp-O-cyclohexyl)-OH

Refernces