C₁₇H₁₅BrF₃N₃O₂

Base Information

• Chemical Name: C₁₇H₁₅BrF₃N₃O₂
• CAS No.: 1295605-47-8
• Molecular Formula: C₁₇H₁₅BrF₃N₃O₂
• Molecular Weight: 430.224
• Mol file: 1295605-47-8.mol

Synonyms:C₁₇H₁₅BrF₃N₃O₂

Chemical Property of C₁₇H₁₅BrF₃N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₅BrF₃N₃O₂

There total 3 articles about C₁₇H₁₅BrF₃N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-methyl-3-(trifluoromethyl)aniline (2026-70-2) + ethyl 3-bromo-4-aminobenzoate (7149-03-3) → C17H15BrF3N3O2 (1295605-47-8)

Guidance literature:

ethyl 3-bromo-4-aminobenzoate; With hydrogenchloride; In acetonitrile; at -10 - 20 ℃; for 0.25h;

With sodium nitrite; In acetonitrile; for 0.5h; Cooling;

N-methyl-3-(trifluoromethyl)aniline; With potassium carbonate; In water; acetonitrile; at -10 - 20 ℃; for 0.5h;

DOI:10.1021/ja2007438

Reference yield:

ethyl (3-(trifluoromethyl)phenyl)carbamate (2354-93-0) → C17H15BrF3N3O2 (1295605-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere; Reflux

2.1: hydrogenchloride / acetonitrile / 0.25 h / -10 - 20 °C

2.2: 0.5 h / Cooling

2.3: 0.5 h / -10 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; In diethyl ether; acetonitrile;

DOI:10.1021/ja2007438

Reference yield:

3-trifluoromethylaniline (98-16-8) → C17H15BrF3N3O2 (1295605-47-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran

2.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere; Reflux

3.1: hydrogenchloride / acetonitrile / 0.25 h / -10 - 20 °C

3.2: 0.5 h / Cooling

3.3: 0.5 h / -10 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether; acetonitrile;

DOI:10.1021/ja2007438

upstream raw materials:

ethyl (3-(trifluoromethyl)phenyl)carbamate

N-methyl-3-(trifluoromethyl)aniline

ethyl 3-bromo-4-aminobenzoate

3-trifluoromethylaniline

Downstream raw materials:

C₁₆H₁₂F₃N₃O₂

Refernces