Technology Process of N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide
There total 11 articles about N-<5-(benzyloxycarbonyl)-1,2,4-trimethylpyrrol-3-yl>-4-<(tert-butyloxycarbonyl)amino>-1,3,5-trimethylpyrrole-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic acid;
In
N,N-dimethyl-formamide;
1.) 20 deg C, 2 d, 2.) 40 deg C, overnight;
DOI:10.1021/jm00133a008
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / NaH / 90 °C / 10 Torr
2: 75 percent / diphenylphosphoryl azide (DPPA), Et3N / acetonitrile / 1.5 h / 50 °C
3: 95 percent / CuCl / 5 h / 60 °C
4: H2 / 10percent Pd/C / dioxane / 12 h
5: Et3N, 2-chloro-1-methylpyridinium iodide / CH2Cl2 / 0.25 h / 0 °C
6: 70 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight
With
diphenylphosphoranyl azide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium hydride; acetic acid; triethylamine; copper(l) chloride;
palladium on activated charcoal;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00133a008
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Et3N / acetonitrile / 5 h / 50 °C
2: H2 / 10percent Pd/C / methanol
3: 100 percent / Na / 4 h / 100 °C
5: H2 / 10percent Pd/C / dioxane / 12 h
6: Et3N, 2-chloro-1-methylpyridinium iodide / CH2Cl2 / 0.25 h / 0 °C
7: 70 percent / glacial AcOH / dimethylformamide / 1.) 20 deg C, 2 d, 2.) 40 deg C, overnight
With
2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium; acetic acid; triethylamine;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00133a008