N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide

Base Information

• Chemical Name: N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide
• CAS No.: 102831-21-0
• Molecular Formula: C₁₇H₁₅NO₄
• Molecular Weight: 297.31
• Mol file: 102831-21-0.mol

Synonyms:N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide

Chemical Property of N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide

There total 4 articles about N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzo[1,3]dioxol-5-yl)-2-bromoethanone (40288-65-1) → N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide (102831-21-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / sodium azide / dimethylsulfoxide / 0.5 h / 10 °C

2: 85 percent / HCl, H₂ / 10percent Pd/C / methanol / 5 h / 2327.2 Torr / Ambient temperature

3: 82 percent / sodium formate / 1 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 0 deg C, 1 h

With hydrogenchloride; sodium azide; hydrogen; sodium formate; sodium hydride; palladium on activated charcoal; In methanol; dimethyl sulfoxide;

DOI:10.1021/jo00367a026

Reference yield:

2-azido-1-(benzo[d][1,3]dioxol-5-yl)ethan-1-one (102831-07-2) → N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide (102831-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / HCl, H₂ / 10percent Pd/C / methanol / 5 h / 2327.2 Torr / Ambient temperature

2: 82 percent / sodium formate / 1 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 0 deg C, 1 h

With hydrogenchloride; hydrogen; sodium formate; sodium hydride; palladium on activated charcoal; In methanol;

DOI:10.1021/jo00367a026

Reference yield:

2-amino-1-benzo[1,3]dioxol-5-yl-ethanone; hydrochloride (38061-34-6) → N-(2-Benzo[1,3]dioxol-5-yl-1-benzyl-2-oxo-ethyl)-formamide (102831-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / sodium formate / 1 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 0 deg C, 1 h

With sodium formate; sodium hydride;

DOI:10.1021/jo00367a026

upstream raw materials:

benzyl bromide

3,4-(methylenedioxy)phenacylformamide

1-(benzo[1,3]dioxol-5-yl)-2-bromoethanone

2-amino-1-benzo[1,3]dioxol-5-yl-ethanone; hydrochloride

Downstream raw materials:

2-Amino-1-benzo[1,3]dioxol-5-yl-3-phenyl-propan-1-one; hydrobromide

Refernces