3-chloro-4-hydroxybenzenesulfonic acid

Base Information

• Chemical Name: 3-chloro-4-hydroxybenzenesulfonic acid
• CAS No.: 46060-27-9
• Molecular Formula: C₆H₅ClO₄S
• Molecular Weight: 208.622
• Mol file: 46060-27-9.mol

Synonyms:3-chloro-4-hydroxybenzenesulfonic acid

Chemical Property of 3-chloro-4-hydroxybenzenesulfonic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-4-hydroxybenzenesulfonic acid

There total 8 articles about 3-chloro-4-hydroxybenzenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Chloro-4-hydroxy-benzenesulfonic acid 2,4-dinitro-phenyl ester → 2,4-Dinitrophenol (51-28-5) + 3-chloro-4-hydroxybenzenesulfonic acid (46060-27-9)

Guidance literature:

With water; at 60 ℃; Rate constant; μ = 1.0, pH 6.3-13.0;

DOI:10.1021/jo961024k

Reference yield:

2-monochlorophenol (95-57-8) → 3-chloro-4-hydroxybenzenesulfonic acid (46060-27-9)

Guidance literature:

With sulfur trioxide; In nitromethane; at 0 ℃; for 4h;

DOI:10.1002/recl.19881070303

Reference yield:

2-monochlorophenol (95-57-8) → 3-chloro-4-hydroxybenzenesulfonic acid (46060-27-9) + 5-chloro-4-hydroxy-benzene-1,3-disulfonic acid (120161-24-2) + 2-chloro-1-hydroxybenzene-6-sulfonic acid (88234-08-6)

Guidance literature:

With sulfuric acid; In water; at 20 ℃; for 23.8889h; Title compound not separated from byproducts;

DOI:10.1002/recl.19881070303

upstream raw materials:

p-hydoroxybenzenesulfonic acid

2-monochlorophenol

Downstream raw materials:

2-chloro-4,6-dinitro-phenol

2-monochlorophenol

Refernces

• 1、 -. "Process for aryl-quinone and aryl-naphthoquinone diazide sulfonic acids". . . Retrieved 2008/06/13.
• 2、 de Wit, Peter,Woldhuis, Alex F.,Cerfontain, Hans. "On the intermediacy of phenyl hydrogen sulfates in the sulfonation of phenols. Sulfonation of phenol, anisole, methyl phenyl sulfate, the 2-halogenophenols, a series of phenyl methanesulfonates together with 2,6-dimethylaniline and its N-methylsulfonyl derivative". . p. 668 - 675. Retrieved 2007/10/02.