(2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester

Base Information

• Chemical Name: (2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester
• CAS No.: 128967-40-8
• Molecular Formula: C₁₆H₁₇N₂O₄P
• Molecular Weight: 332.296
• Mol file: 128967-40-8.mol

Synonyms:(2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester

Chemical Property of (2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester

There total 3 articles about (2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-phenylimino-2-indolinone (33828-98-7,101671-27-6) + Dimethyl phosphite (868-85-9) → (2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester (128967-40-8)

Guidance literature:

at 100 ℃; for 8h;

Reference yield: 87.0%

3-phenylimino-2-indolinone (33828-98-7,101671-27-6) + phosphorous acid trimethyl ester (121-45-9) → (2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester (128967-40-8)

Guidance literature:

With acetic acid; at 100 ℃; for 10h; Product distribution; Mechanism; also with water and without protonating agent; other time; 3-(arylium)-2-oxindoles and trialkyl phosphites;

Reference yield: 81.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + Dimethyl phosphite (868-85-9) + aniline (62-53-3) → (2-Oxo-3-phenylamino-2,3-dihydro-1H-indol-3-yl)-phosphonic acid dimethyl ester (128967-40-8)

Guidance literature:

With phosphotungstic acid supported on silica-coated magnetic Fe₃O₄ nanoparticle; In neat (no solvent); at 80 ℃; for 16h; Green chemistry;

DOI:10.1002/cplu.201402191

upstream raw materials:

3-phenylimino-2-indolinone

Dimethyl phosphite

phosphorous acid trimethyl ester

indole-2,3-dione

Downstream raw materials:

3-phenylimino-2-indolinone

Dimethyl phosphite

Refernces

• 1、 Abdou, Wafaa M.,Abd El-Rahman, Naglaa M.,Mahran, Mohamed R. H.. "The Behaviour of 3-Aryliminoxindoles toward Alkyl Phosphites". . p. 906 - 912. Retrieved 2007/10/02.