Salinomycin sodium salt

Base Information

• Chemical Name: Salinomycin sodium salt
• CAS No.: 55721-31-8
• Molecular Formula: C42H69O11.Na
• Molecular Weight: 772.993
• European Community (EC) Number: 611-309-0
• Mol file: 55721-31-8.mol

Synonyms:Salinomycin sodium salt;55721-31-8;SR-05000002207;C42H70O11.Na;C42-H70-O11.Na;C42-H70-O11;YPZYGIQXBGHDBH-UZHRAPRISA-N;AKOS026749973;LS-184462;SR-05000002207-2;SR-05000002207-4

Chemical Property of Salinomycin sodium salt

Chemical Property:

• Appearance/Colour: Brown solid
• Melting Point: 140-142oC
• PSA: 173.27000
• LogP: 4.78900
• Storage Temp.: APPROX 4°C
• Solubility.: Soluble in DMSO.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 12
• Exact Mass: 773.48158233
• Heavy Atom Count: 54
• Complexity: 1320

Purity/Quality:

99% ^*data from raw suppliers

SalinomycinSodiumSalt(12%min.) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O.[Na+]
• Isomeric SMILES: CC[C@H]([C@H]1CC[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C(=O)O.[Na+]
• Uses: Salinomycin is safe and effective coccidiostat,which has inhibitory effect on most Gram-positive bacteria ,it also has effect on chicken coccidiosis, soft Ehrlich, Ehrlich poison, giant Ehrlich, Ehrlich and heap-shaped ball Harrington insects. It can be used for chicken feed, the amount is 50-60g/t,it should be stopped during laying period, the period is 5 days. Equine animals are hanged, it causes death after use; and it is banned using it with tiamulin, oleandomycin simultaneously. The above information is edited by the lookchem of Tian Ye. Salinomycin is an ionophore agent. Salinomycin sodium is prepared from salinomycin taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. The sodium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Salinomycin has a high affinity for monovalent cations, particularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells.
• production method: It is produced by fermentation of white Streptomyces (Streptomyces albus).
• Description: Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1?Salinomycin Na displays selective toxicity for cancer stem cells.1?Induces rapid mitochondrial hyperpolarization.2?Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3?Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4?Kills cancer stem cells by sequestering iron.5

Technology Process of Salinomycin sodium salt

There total 5 articles about Salinomycin sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

salinomycin trimethylsilyl ethyl ester → salinomycin SV sodium salt (55721-31-8)

Guidance literature:

salinomycin trimethylsilyl ethyl ester; With tetrabutyl ammonium fluoride; In tetrahydrofuran; Inert atmosphere;

With sodium carbonate; In water; Inert atmosphere;

DOI:10.1002/chem.201603621

Reference yield: 100.0%

C65H124O11Si4 → salinomycin SV sodium salt (55721-31-8)

Guidance literature:

C₆₅H₁₂₄O₁₁Si₄; With tetrabutyl ammonium fluoride; In tetrahydrofuran; Inert atmosphere;

With sodium carbonate; In water; Inert atmosphere;

DOI:10.1002/chem.201603621

Reference yield: 41.0%

C45H74O11 → salinomycin SV sodium salt (55721-31-8)

Guidance literature:

C₄₅H₇₄O₁₁; With morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,2-bis-(diphenylphosphino)ethane; In dichloromethane; Inert atmosphere;

With sodium carbonate; In dichloromethane; water; Inert atmosphere;

DOI:10.1002/chem.201603621

upstream raw materials:

salinomycin

Downstream raw materials:

salinomycin 4-methoxybenzyl ester

salinomycin benzyl ester

salinomycin

Refernces

• 1、 Antoszczak, Micha?,Cioch, Aleksandra,Czerwonka, Dominika,Huczyński, Adam,Mielczarek-Puta, Magdalena,Struga, Marta. "Evaluation of the anticancer activity of singly and doubly modified analogues of C20-epi-salinomycin". . . Retrieved 2021.