Technology Process of C16H22INO2
There total 11 articles about C16H22INO2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
di-tert-butyl dicarbonate; potassium carbonate;
In
dichloromethane;
at 23 ℃;
for 12h;
DOI:10.1016/j.bmcl.2008.09.081
- Guidance literature:
-
With
sodium carbonate;
In
dichloromethane;
at 5 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 24 h / 80 °C
2.1: hydrogenchloride / dichloromethane; water / 96 h / Heating / reflux
3.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 30 °C
4.1: hydrogen / palladium on activated charcoal / methanol / 3 - 4 h / 40 °C / 2585.81 Torr
5.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 30 °C
5.2: 2 h / 0 - 25 °C
6.1: thionyl chloride / 4 h / 0 °C / Heating / reflux
7.1: sodium hydride / tetrahydrofuran / 3 h / Heating / reflux
8.1: hydrogenchloride / tetrahydrofuran; water; isopropyl alcohol / 14 h / Heating / reflux
9.1: sodium tetrahydroborate / methanol; acetic acid / 2.5 h / -60 - -40 °C
10.1: sodium carbonate / dichloromethane / 5 - 20 °C
With
hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; thionyl chloride; water; hydrogen; sodium hydride; sodium carbonate; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0); palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;