N-Acryloyl-2-methylalanine

Base Information

• Chemical Name: N-Acryloyl-2-methylalanine
• CAS No.: 29513-50-6
• Molecular Formula: C7H11 N O3
• Molecular Weight: 157.169
• Mol file: 29513-50-6.mol

Synonyms:Alanine,2-methyl-N-(1-oxo-2-propenyl)- (9CI); Alanine, N-acryloyl-2-methyl- (8CI);2-Acrylamido-2-methylpropanoic acid; NSC 288647

Chemical Property of N-Acryloyl-2-methylalanine

Chemical Property:

• Vapor Pressure: 1.64E-06mmHg at 25°C
• Boiling Point: 370.7°Cat760mmHg
• Flash Point: 178°C
• PSA: 66.40000
• Density: 1.124g/cm³
• LogP: 0.54270

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Acryloyl-2-methylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Acryloyl-2-methylalanine

There total 2 articles about N-Acryloyl-2-methylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-Aminoisobutyric acid (62-57-7) + acryloyl chloride (814-68-6,25189-84-8) → 2-methyl-2-(prop-2-enamido)propanoic acid (29513-50-6)

Guidance literature:

2-Aminoisobutyric acid; With 2,6-di-tert-butyl-4-methyl-phenol; sodium hydroxide; In water; Cooling with ice;

acryloyl chloride; In water; at 0 ℃; for 3h;

With hydrogenchloride; In water; for 0.5h;

DOI:10.1039/c2cc37181b

Reference yield: 60.0%

2-acrylamido-2-methylpropionitrile (86350-96-1) → 2-methyl-2-(prop-2-enamido)propanoic acid (29513-50-6)

Guidance literature:

With sulfuric acid; at 70 ℃; for 3h;

Reference yield: 80.0%

2-methyl-2-(prop-2-enamido)propanoic acid (29513-50-6) → vinyl azlactone (29513-26-6)

Guidance literature:

With chloroformic acid ethyl ester;

upstream raw materials:

2-acrylamido-2-methylpropionitrile

2-Aminoisobutyric acid

acryloyl chloride

Downstream raw materials:

vinyl azlactone

Refernces

• 1、 Duong, Hien T. T.,Kamarudin, Zulkamal M.,Erlich, Rafael B.,Li, Yang,Jones, Mathew W.,Kavallaris, Maria,Boyer, Cyrille,Davis, Thomas P.. "Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers". supporting information. p. 4190 - 4192. Retrieved 2013/05/23.