6-phenylnaphthalen-2-yl pivalate

Base Information

• Chemical Name: 6-phenylnaphthalen-2-yl pivalate
• CAS No.: 1122065-34-2
• Molecular Formula: C₂₁H₂₀O₂
• Molecular Weight: 304.389
• Mol file: 1122065-34-2.mol

Synonyms:6-phenylnaphthalen-2-yl pivalate

Chemical Property of 6-phenylnaphthalen-2-yl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-phenylnaphthalen-2-yl pivalate

There total 5 articles about 6-phenylnaphthalen-2-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

6-bromonaphthyl pivalate + phenylboronic acid (98-80-6) → 6-phenylnaphthalen-2-yl pivalate (1122065-34-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In water; toluene; at 90 ℃; for 12h; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1002/adsc.201800729

Reference yield: 63.0%

6-bromonaphthalen-2-yl pivalate (1533458-03-5) + phenylboronic acid (98-80-6) → 6-phenylnaphthalen-2-yl pivalate (1122065-34-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In water; toluene; at 90 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja410883p

Reference yield:

6-phenylnaphthalen-2-ol (475278-17-2) + pivaloyl chloride (3282-30-2) → 6-phenylnaphthalen-2-yl pivalate (1122065-34-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.orglett.7b00556

upstream raw materials:

pivaloyl chloride

6-bromo-naphthalen-2-ol

6-bromonaphthalen-2-yl pivalate

phenylboronic acid

Downstream raw materials:

6-phenyl-2-naphthoic acid

2-phenyl-6-(2,4,5-trimethylphenyl)naphthalene

Refernces

• 1、 Tang, Jinghua,Liu, Liu Leo,Yang, Shangru,Cong, Xuefeng,Luo, Meiming,Zeng, Xiaoming. "Chemoselective Cross-Coupling between Two Different and Unactivated C(aryl)-O Bonds Enabled by Chromium Catalysis". supporting information. p. 7715 - 7720. Retrieved 2020/05/20.
• 2、 Chen, Quan,Wu, Aizhen,Qin, Shengxiang,Zeng, Meiqi,Le, Zhiping,Yan, Zhaohua,Zhang, Hua. "Ni-Catalyzed Decarboxylative Cross-Coupling of Potassium Polyfluorobenzoates with Unactivated Phenol and Phenylmethanol Derivatives". supporting information. p. 3239 - 3244. Retrieved 2018/09/10.