α-deuterio-1-methoxy-4-vinylbenzene

Base Information

• Chemical Name: α-deuterio-1-methoxy-4-vinylbenzene
• CAS No.: 193361-04-5
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 135.17
• Mol file: 193361-04-5.mol

Synonyms:α-deuterio-1-methoxy-4-vinylbenzene

Chemical Property of α-deuterio-1-methoxy-4-vinylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-deuterio-1-methoxy-4-vinylbenzene

There total 13 articles about α-deuterio-1-methoxy-4-vinylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(1-chloroethenyl)-4-methoxybenzene (40811-01-6) → α-deuterio-1-methoxy-4-vinylbenzene (193361-04-5)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); 1-deuteriodiphenylmethanol; 3-(2,6-dibenzhydryl-4-methylphenyl)-4,5-dimethyl-1-(2,4,6-trimethylbenzyl)imidazolium chloride; caesium carbonate; In toluene; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.oprd.9b00193

Reference yield: 77.0%

α-deutero-anisaldehyde + Methylenetriphenylphosphorane (19493-09-5) → α-deuterio-1-methoxy-4-vinylbenzene (193361-04-5)

Guidance literature:

In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/ja017736w

Reference yield: 11.0%

(E)-N′-(1-(4-methoxyphenyl)ethylidene)-4-methylbenzenesulfonohydrazide (1228679-43-3) → α-deuterio-1-methoxy-4-vinylbenzene (193361-04-5)

Guidance literature:

(E)-N′-(1-(4-methoxyphenyl)ethylidene)-4-methylbenzenesulfonohydrazide; With dimesitylmagnesium; lithium chloride; In tetrahydrofuran; at 0 ℃; for 3h;

With water-d2; In tetrahydrofuran;

DOI:10.1021/ol300652k

upstream raw materials:

Methylenetriphenylphosphorane

p-methoxyphenylmethanol-1,1-d2

4-methoxy-benzoyl chloride

1-(4-methoxyphenyl)ethanone

Refernces

• 1、 Onodera, Shunsuke,Togashi, Ryo,Ishikawa, Soya,Kochi, Takuya,Kakiuchi, Fumitoshi. "Catalytic, Directed C-C Bond Functionalization of Styrenes". supporting information. p. 7345 - 7349. Retrieved 2020/08/19.
• 2、 Gao, Fang,Hoveyda, Amir H.. "α-Selective Ni-catalyzed hydroalumination of aryl- and alkyl-substituted terminal alkynes: Practical syntheses of internal vinyl aluminums, halides, or boronates". supporting information; experimental part. p. 10961 - 10963. Retrieved 2010/09/17.