Bis(p-acetylaminophenyl) ether

Base Information

• Chemical Name: Bis(p-acetylaminophenyl) ether
• CAS No.: 3070-86-8
• Molecular Formula: C16H16 N2 O3
• Molecular Weight: 284.315
• Hs Code.: 2924299090
• NSC Number: 19584
• UNII: LT12J9ECA9
• DSSTox Substance ID: DTXSID00184733
• Nikkaji Number: J866.232K
• Wikidata: Q83055664
• Mol file: 3070-86-8.mol

Synonyms:4,4'-diacetamidodiphenyl ether

Chemical Property of Bis(p-acetylaminophenyl) ether

Chemical Property:

• Melting Point: 230-231 °C(lit.)
• Boiling Point: 554.4°Cat760mmHg
• PKA: 14.16±0.70(Predicted)
• Flash Point: 289.1°C
• PSA: 67.43000
• Density: 1.256g/cm³
• LogP: 3.54170
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 284.11609238
• Heavy Atom Count: 21
• Complexity: 323

Purity/Quality:

99% ^*data from raw suppliers

Bis(p-acetylaminophenyl)Ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)OC2=CC=C(C=C2)NC(=O)C
• Uses: N,N'-(Oxydi-4,1-Phenylene)Bisacetamide is a chemical reagent used in the synthesis of photosensitive polymer compounds and optical application. It also is used in the preparation of benzimidazole derivatives displaying anti-tumor activity through apoptosis.

Technology Process of Bis(p-acetylaminophenyl) ether

There total 12 articles about Bis(p-acetylaminophenyl) ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-[4-(4-aminophenoxy)phenyl]acetamide (2687-41-4) + acetic anhydride (108-24-7) → N-[4-(4-acetylaminophenoxy)phenyl]acetamide (3070-86-8)

Guidance literature:

DOI:10.1007/s11176-005-0459-8

Reference yield: 98.0%

acetic anhydride (108-24-7) + 4,4'-oxydiphenylene diamine (101-80-4,121509-79-3) → N-[4-(4-acetylaminophenoxy)phenyl]acetamide (3070-86-8)

Guidance literature:

In acetone; at 0 ℃;

DOI:10.1016/j.bmcl.2012.06.102

Reference yield: 98.0%

4,4'-oxydiphenylene diamine (101-80-4,121509-79-3) + acetic acid (64-19-7,77671-22-8) → N-[4-(4-acetylaminophenoxy)phenyl]acetamide (3070-86-8)

Guidance literature:

at 110 ℃; for 7h; Temperature; Reagent/catalyst;

upstream raw materials:

acetic anhydride

4,4'-oxydiphenylene diamine

acetic acid

N-[4-(4-aminophenoxy)phenyl]acetamide

Downstream raw materials:

N-[4-(4-acetylamino-3-nitrophenoxy)-2-nitrophenyl]acetamide

5,5'-oxy-bis[2-(4'-methoxyphenyl)-1H-benzimidazole]

5,5'-oxy-bis[2-(3',5'-dimethoxyphenyl)-1H-benzimidazole]

5,5'-oxy-bis[2-(3',4',5'-trimethoxyphenyl)-1H-benzimidazole]

Refernces

• 1、 Wang, Xiu-Jun,Yang, Ming-Li,Zhang, Lan-Ping,Yao, Tong,Chen, Cheng,Mao, Lian-Gang,Wang, Yin,Wu, Jie. "Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents". . p. 589 - 592. Retrieved 2014/05/06.
• 2、 Pilyugin,Sapozhnikov,Kiseleva,Sapozhnikova,Vorob'eva,Klimakova. "Synthesis and structure of Di[methoxy(ethoxy)carbonylamino-1H-benzimidazol- 5-yl] ethers". . p. 1509 - 1513. Retrieved 2007/10/03.