C₂₅H₂₇NO₆S

Base Information

• Chemical Name: C₂₅H₂₇NO₆S
• CAS No.: 1275597-30-2
• Molecular Formula: C₂₅H₂₇NO₆S
• Molecular Weight: 469.558
• Mol file: 1275597-30-2.mol

Synonyms:C₂₅H₂₇NO₆S

Chemical Property of C₂₅H₂₇NO₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₇NO₆S

There total 8 articles about C₂₅H₂₇NO₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C25H27NO5S (1275597-29-9) → C25H27NO6S (1275597-30-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 ℃; for 0.25h;

DOI:10.1021/jo1022487

Reference yield:

naltrexone methyl ether (16617-07-5) → C25H27NO6S (1275597-30-2)

Guidance literature:

Multi-step reaction with 11 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / 0.5 h / 0 °C / Inert atmosphere

2.1: pyridine / 0.25 h / 0 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

4.1: lithium triethylborohydride / tetrahydrofuran / 24 h / 0 - 60 °C / Inert atmosphere

4.2: 1 h / 0 °C / Reflux

5.1: 1 h / Inert atmosphere; Reflux

6.1: potassium carbonate / 1,1,2,2-tetrachloroethane / 12 h / 150 °C / Inert atmosphere

7.1: potassium hydroxide / water; dimethyl sulfoxide / 12 h / 110 °C / Inert atmosphere

8.1: N-chloro-succinimide / chloroform / 0.5 h / -30 °C / Inert atmosphere

9.1: 15-crown-5; sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

9.2: 11 h

10.1: lithium diisopropyl amide / tetrahydrofuran; hexane] / 1 h / -78 - 0 °C / Inert atmosphere

10.2: 2.5 h / 20 °C / Inert atmosphere

11.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.25 h / -78 °C

With pyridine; N-chloro-succinimide; 15-crown-5; potassium tert-butylate; sodium tris(acetoxy)borohydride; sodium hydride; lithium triethylborohydride; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; chloroform; hexane]; water; dimethyl sulfoxide; 1,1,2,2-tetrachloroethane; 9.1: Grob fragmentation;

DOI:10.1021/jo1022487

Reference yield:

C21H26INO3 → C25H27NO6S (1275597-30-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

1.2: 30 h / 20 °C

2.1: 1 h / Inert atmosphere; Reflux

3.1: potassium carbonate / 1,1,2,2-tetrachloroethane / 12 h / 150 °C / Inert atmosphere

4.1: potassium hydroxide / water; dimethyl sulfoxide / 12 h / 110 °C / Inert atmosphere

5.1: N-chloro-succinimide / chloroform / 0.5 h / -30 °C / Inert atmosphere

6.1: 15-crown-5; sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

6.2: 11 h

7.1: lithium diisopropyl amide / tetrahydrofuran; hexane] / 1 h / -78 - 0 °C / Inert atmosphere

7.2: 2.5 h / 20 °C / Inert atmosphere

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.25 h / -78 °C

With N-chloro-succinimide; 15-crown-5; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; chloroform; hexane]; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,1,2,2-tetrachloroethane; 6.1: Grob fragmentation;

DOI:10.1021/jo1022487

upstream raw materials:

C₂₃H₂₉NO₄

C₂₂H₂₄Cl₃NO₆

C₁₇H₂₁NO₃

C₁₇H₂₀ClNO₃

Refernces