Technology Process of O6-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine
There total 4 articles about O6-((3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl)guanine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3-((2-(2-(2-(2,2,2-trifluoroacetamido)ethoxy)ethoxy)ethoxy)methyl))benzyl alcohol;
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.0833333h;
1‐(2‐amino‐9H‐purin‐6‐yl)‐1‐methylpyrrolidin‐1‐ium chloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
DOI:10.1039/c2ob25231g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C
1.2: 3 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux
3.1: triethylamine / ethanol / 5 h / 20 °C
4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.08 h / 0 °C
4.2: 3 h / 20 °C
With
lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride; triethylamine;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c2ob25231g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux
2.1: triethylamine / ethanol / 5 h / 20 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.08 h / 0 °C
3.2: 3 h / 20 °C
With
lithium aluminium tetrahydride; potassium tert-butylate; triethylamine;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25231g
