1-(Hydroxy-phenyl-methyl)-cyclopropanol

Base Information

• Chemical Name: 1-(Hydroxy-phenyl-methyl)-cyclopropanol
• CAS No.: 246180-23-4
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.204
• Mol file: 246180-23-4.mol

Synonyms:1-(Hydroxy-phenyl-methyl)-cyclopropanol

Chemical Property of 1-(Hydroxy-phenyl-methyl)-cyclopropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Hydroxy-phenyl-methyl)-cyclopropanol

There total 2 articles about 1-(Hydroxy-phenyl-methyl)-cyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-phenylmethylenecyclopropane (7555-67-1) → 1-(Hydroxy-phenyl-methyl)-cyclopropanol (246180-23-4)

Guidance literature:

With osmium(VIII) oxide;

DOI:10.1016/0040-4039(94)02452-H

Reference yield:

benzaldehyde (100-52-7) → 1-(Hydroxy-phenyl-methyl)-cyclopropanol (246180-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Wittig reaction

2: 67 percent / 0.2-1.0 molpercent OsO₄

With osmium(VIII) oxide;

DOI:10.1016/0040-4039(94)02452-H

Reference yield: 94.3%

1-(Hydroxy-phenyl-methyl)-cyclopropanol (246180-23-4) → 2-phenylcyclobutanone (42436-86-2)

Guidance literature:

With thionyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 12h;

DOI:10.1016/0040-4039(94)02452-H

upstream raw materials:

1-phenylmethylenecyclopropane

benzaldehyde

Downstream raw materials:

2-phenylcyclobutanone

Refernces

• 1、 Nemoto, Hideo,Miyata, Junji,Hakamata, Hideki,Fukumoto, Keiichiro. "The First Example of Asymmetric Dihydroxylation of Cyclopropylidene Derivatives --- An Enantioenriched Formal Total Synthesis of (-)-Filiformin". . p. 1055 - 1058. Retrieved 2007/10/02.