3-fluorobenzhydryl chloride

Base Information

• Chemical Name: 3-fluorobenzhydryl chloride
• CAS No.: 13391-48-5
• Molecular Formula: C₁₃H₁₀ClF
• Molecular Weight: 220.674
• Mol file: 13391-48-5.mol

Synonyms:3-fluorobenzhydryl chloride

Chemical Property of 3-fluorobenzhydryl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluorobenzhydryl chloride

There total 4 articles about 3-fluorobenzhydryl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-fluoro-α-phenyl benzenemethanol (365-17-3) → 3-fluorobenzhydryl chloride (13391-48-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1002/ejoc.200901400

Reference yield:

3-fluorobenzophenone (345-69-7) → 3-fluorobenzhydryl chloride (13391-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol

2: SOCl₂ / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; In ethanol;

DOI:10.1021/jm950782k

Reference yield:

3-fluorobenzoyl chloride (1711-07-5) → 3-fluorobenzhydryl chloride (13391-48-5)

Guidance literature:

Multi-step reaction with 3 steps

2: NaBH₄ / propan-2-ol

3: HCl, Drierite / CH₂Cl₂

With hydrogenchloride; calcium sulfate; sodium tetrahydroborate; In dichloromethane; isopropyl alcohol;

DOI:10.1021/jo01284a600

upstream raw materials:

3-fluoro-α-phenyl benzenemethanol

3-fluorobenzophenone

3-fluorobenzoyl chloride

benzene

Downstream raw materials:

3-fluoro-α-phenyl benzenemethanol

2-(2-{2-[3-(3-fluoro-phenyl)-3-phenyl-propyl]-1H-imidazol-4-yl}-ethyl)-isoindole-1,3-dione

2-((3-fluorophenyl)phenylmethyl)malonic acid

3-(3-fluorophenyl)-3-phenylpropionic acid

Refernces

• 1、 Kline, Richard H.,Izenwasser, Sari,Katz, Jonathan L.,Joseph, David B.,Bowen, Wayne D.,Newman, Amy Hauck. "3'-Chloro-3α-(diphenylmethoxy)tropane but not 4'-chloro-3α- (diphenylmethoxy)tropane produces a cocaine-like behavioral profile". . p. 851 - 857. Retrieved 2007/10/03.