3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde

Base Information

• Chemical Name: 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde
• CAS No.: 83324-59-8
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.595
• Mol file: 83324-59-8.mol

Synonyms:3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde

Chemical Property of 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

3-Chloro-4,6-dihydroxy-2-methylbenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-chloro-4,6-dihydroxy-2-methylbenzaldehyde is a lichen/fungal metabolite.

Technology Process of 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde

There total 10 articles about 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-chloro-4,6-dimethoxy-2-methylbenzaldehyde (878479-97-1) → 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde (83324-59-8)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1002/jhet.5570430105

Reference yield: 76.5%

2,4-dihydroxy-6-methylbenzaldehyde (487-69-4) → 3-chloro-2,4-dihydroxy-6-methyl-benzaldehyde (106325-72-8) + 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde (83324-59-8)

Guidance literature:

With sulfuryl dichloride; In diethyl ether; 1.) 0 deg C, 1.5 h, 2.) r.t., 8 h;

DOI:10.1016/S0040-4020(01)90548-4

Reference yield: 75.0%

2,4-dihydroxy-6-methylbenzaldehyde (487-69-4) → 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde (83324-59-8)

Guidance literature:

With sulfuryl dichloride; In diethyl ether; at 0 - 20 ℃;

DOI:10.1021/jo00221a009

upstream raw materials:

2,4-dihydroxy-6-methylbenzaldehyde

4-chloro-5-methylbenzene-1,3-diol

3-chloro-4,6-dimethoxy-2-methylbenzaldehyde

1,3-dimethoxy-5-methylbenzene

Downstream raw materials:

5-chloro-2,4-dihydroxy-6-methyl-3-(3-methyl-2-butenyl)benzaldehyde

1,5-diacetoxy-2-chloro-4-diacetoxymethyl-3-methyl-benzene

2-chloro-4-formyl-5-hydroxy-3-methylphenyl acetate

(2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethyl-2,6-octadienyl pivalate

Refernces

• 1、 -. "COMPOUNDS FOR USE AS INHIBITORS OF ALTERNATIVE OXIDASE OR CYTOCHROME BC1 COMPLEX". Page/Page column 24-25. . Retrieved 2013/11/18.
• 2、 Yamaguchi, Seiji,Maekawa, Mikiko,Murayama, Yohei,Miyazawa, Masahiro,Hirai, Yoshiro. "New approach for two chromene carboxylic acids having a fully substituted benzene ring". . p. 6971 - 6973. Retrieved 2007/10/03.