Technology Process of 2-{3-[(1R,2R)-2-carboxy-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid
There total 7 articles about 2-{3-[(1R,2R)-2-carboxy-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-{3-[(1R,2R)-2-ethoxycarbonyl-2-hydroxy-1-(2-trifluoromethyl-benzyl)-ethylcarbamoyl]-propyl}-benzoic acid;
With
water; sodium hydroxide;
In
tetrahydrofuran;
for 4h;
With
acetic acid;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydroxide; water / acetone / 0 °C / pH 8 - 9
1.2: pH 1
1.3: pH 1
2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C
4.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C
5.1: hydrogenchloride / 1,4-dioxane / Reflux
5.2: 4 h / Reflux
6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h
7.1: sodium hydroxide; water / tetrahydrofuran / 4 h
With
hydrogenchloride; lithium aluminium tetrahydride; water; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C
2.1: hydrogenchloride / 1,4-dioxane / Reflux
2.2: 4 h / Reflux
3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h
4.1: sodium hydroxide; water / tetrahydrofuran / 4 h
With
hydrogenchloride; water; sodium hydrogensulfite; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;