Technology Process of O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>4)-3-O-allyl-6-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl azide
There total 5 articles about O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>4)-3-O-allyl-6-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl azide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaOMe, 2.) HBF4 / 1.) CH2Cl2, MeOH, RT, 1.5 h, 2.) MeCN, ether, RT, 1 h
2: 91 percent / 80percent NaH, Bu4NI / tetrahydrofuran / 3 h / 60 °C
3: 55 percent / HCl, NaCNBH3, 3A molecular sieves / diethyl ether; tetrahydrofuran / 1.5 h / Ambient temperature
4: 1.) 4A molecular sives, 2.) BF3*OEt2 / 1.) CH2Cl2, 5 deg C, 1 h, 2.) CH2Cl2, RT, 2 h
With
hydrogenchloride; tetrafluoroboric acid; 3 A molecular sieve; 4A molecular sives; boron trifluoride diethyl etherate; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium cyanoborohydride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/0008-6215(93)84071-D
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaOMe, 2.) HBF4 / 1.) CH2Cl2, MeOH, RT, 1.5 h, 2.) MeCN, ether, RT, 1 h
2: 91 percent / 80percent NaH, Bu4NI / tetrahydrofuran / 3 h / 60 °C
3: 55 percent / HCl, NaCNBH3, 3A molecular sieves / diethyl ether; tetrahydrofuran / 1.5 h / Ambient temperature
4: 1.) 4A molecular sives, 2.) BF3*OEt2 / 1.) CH2Cl2, 5 deg C, 1 h, 2.) CH2Cl2, RT, 2 h
With
hydrogenchloride; tetrafluoroboric acid; 3 A molecular sieve; 4A molecular sives; boron trifluoride diethyl etherate; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium cyanoborohydride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/0008-6215(93)84071-D
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / 80percent NaH, Bu4NI / tetrahydrofuran / 3 h / 60 °C
2: 55 percent / HCl, NaCNBH3, 3A molecular sieves / diethyl ether; tetrahydrofuran / 1.5 h / Ambient temperature
3: 1.) 4A molecular sives, 2.) BF3*OEt2 / 1.) CH2Cl2, 5 deg C, 1 h, 2.) CH2Cl2, RT, 2 h
With
hydrogenchloride; 3 A molecular sieve; 4A molecular sives; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium cyanoborohydride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/0008-6215(93)84071-D