1,2,3-tris(trifluoromethyl)benzene

Base Information

• Chemical Name: 1,2,3-tris(trifluoromethyl)benzene
• CAS No.: 42175-48-4
• Molecular Formula: C9H3F9
• Molecular Weight: 282.108
• Hs Code.: 2903999090
• Mol file: 42175-48-4.mol

Synonyms:

Chemical Property of 1,2,3-tris(trifluoromethyl)benzene

Chemical Property:

• Vapor Pressure: 13.4mmHg at 25°C
• Boiling Point: 127.6°Cat760mmHg
• Flash Point: 33.5°C
• PSA: 0.00000
• Density: 1.485g/cm³
• LogP: 4.74300

Purity/Quality:

99% ^*data from raw suppliers

1,2,3-tris(trifluoromethyl)benzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3-tris(trifluoromethyl)benzene

There total 5 articles about 1,2,3-tris(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzene-1,2,3-tricarboxlic acid (569-51-7) → 1,2,3-Tris-(trifluormethyl)-benzol (42175-48-4) + 2,6-bis(trifluoromethyl)benzoic acid (24821-22-5) + 1,1,3,3-Tetrafluoro-4-trifluoromethyl-1,3-dihydroisobenzofuran

Guidance literature:

With potassium hydroxide; sulfur tetrafluoride; hydrogen fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) 80 deg C, 20 h; 180 deg C, 20 h, 2.) 100 deg C, 48 h;

DOI:10.1016/S0022-1139(96)03541-5

Reference yield:

2,3-Bis-(trifluormethyl)benzoesaeure (42175-55-3) → 1,2,3-Tris-(trifluormethyl)-benzol (42175-48-4)

Guidance literature:

With sulfur tetrafluoride; hydrogen fluoride; at 300 ℃;

Reference yield:

1,2-bis(trifluoromethyl)benzene (433-95-4) → 1,2,3-Tris-(trifluormethyl)-benzol (42175-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) nBuLi, Et₂O, (ii) /BRN= 1900390/

2: SF₄, HF / 300 °C

With sulfur tetrafluoride; hydrogen fluoride;

upstream raw materials:

2,3-Bis-(trifluormethyl)benzoesaeure

benzene-1,2,3-tricarboxlic acid

1,2-bis(trifluoromethyl)benzene

Downstream raw materials:

3,4,5-Tris-trifluoromethyl-benzoic acid

1,2,3,4-Tetrakis-(trifluormethyl)-benzol

1,2-Dibromo-3,4,5-tris-trifluoromethyl-benzene

2,6-bis(trifluoromethyl)benzoic acid

Refernces