C₁₅H₁₁BrO₂

Base Information

• Chemical Name: C₁₅H₁₁BrO₂
• CAS No.: 936257-41-9
• Molecular Formula: C₁₅H₁₁BrO₂
• Molecular Weight: 303.155
• Mol file: 936257-41-9.mol

Synonyms:C₁₅H₁₁BrO₂

Chemical Property of C₁₅H₁₁BrO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₁BrO₂

There total 2 articles about C₁₅H₁₁BrO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromosalicylaldehyde (22532-62-3) + acetophenone (98-86-2) → C15H11BrO2 (936257-41-9)

Guidance literature:

acetophenone; With potassium hydroxide; In methanol; water; for 0.166667h; Cooling with ice;

4-bromosalicylaldehyde; In methanol; water; at 20 ℃; for 12h;

DOI:10.1021/ol3013588

Reference yield:

3-Bromophenol (591-20-8) → C15H11BrO2 (936257-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; magnesium chloride / tetrahydrofuran / 24 h / Reflux

2.1: potassium hydroxide / methanol; water / 0.17 h / Cooling with ice

2.2: 12 h / 20 °C

With triethylamine; potassium hydroxide; magnesium chloride; In tetrahydrofuran; methanol; water;

DOI:10.1021/ol3013588

Reference yield: 99.0%

C15H11BrO2 (936257-41-9) + para-fluorophenyl isocyanate (1195-45-5) → C22H15BrFNO3

Guidance literature:

With C₅₂H₇₀N₈O₂*1.3C₃₂H₁₃BF₂₃^(1-)*1.3H⁽¹⁺⁾; In diethyl ether; at -30 ℃; for 87h; enantioselective reaction;

DOI:10.1021/acs.orglett.6b02522

upstream raw materials:

3-Bromophenol

4-bromosalicylaldehyde

acetophenone

Downstream raw materials:

8-bromo-2-phenyl-3-tosyl-4,4a-dihydro-3H-chromeno[3,4-c]pyridin-5(10bH)-one

Refernces

• 1、 Rouh, Hossein,Liu, Yangxue,Katakam, Nandakumar,Pham, Lilian,Zhu, Yi-Long,Li, Guigen. "Synthesis of Functionalized Chromene and Chroman Derivatives via Cesium Carbonate Promoted Formal [4 + 2] Annulation of 2′-Hydroxychalcones with Allenoates". . p. 15372 - 15379. Retrieved 2019/01/04.