Stronghold

Base Information

• Chemical Name: Stronghold
• CAS No.: 220119-17-5
• Molecular Formula: C₄₃H₆₃NO₁₁
• Molecular Weight: 769.973
• Hs Code.: 2932206000
• European Community (EC) Number: 811-481-9,815-979-7
• DSSTox Substance ID: DTXSID801339341
• Wikipedia: Selamectin
• Wikidata: Q2267471
• NCI Thesaurus Code: C75233
• Mol file: 220119-17-5.mol

Synonyms:25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22 23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide;selamectin

Chemical Property of Stronghold

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.618
• Boiling Point: 917 °C at 760 mmHg
• PKA: 10.34±0.70(Predicted)
• Flash Point: 508.4 °C
• PSA: 154.73000
• Density: 1.35 g/cm³
• LogP: 6.06980
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly), Etha
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 4
• Exact Mass: 769.44011183
• Heavy Atom Count: 55
• Complexity: 1550

Purity/Quality:

99%min ^*data from raw suppliers

Selamectin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1CCC2(CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)O)OC)C)OC1C7CCCCC7
• Isomeric SMILES: C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N\O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7
• Description: Selamectin is formulated as a spot-on for cats and dogs to control fleas (Ctenocephalides spp.) and flea-allergy dermatitis, to prevent heartworm disease, and to control ear mites (Otodectes cynotes) in cats and dogs. It is also approved for the treatment and control of sarcoptic mange (Sarcoptes scabiei) in dogs and hookworms (Ancylostoma tubaeformis) and roundworms (Toxocara cati) in cats. Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. At 0.1 μg/ml, selamectin is reported to inhibit growth in an H. contortus larval development assay.
• Uses: Selamectin is a topical parasiticide and also used as a veterinary antihelminithic agent on animals. Selamectin is a semi-synthetic avermectin derivative prepared by selective hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of endo- and exo- parasites of domestic animals, notably cats and dogs. Like the other milbemycin/avermectins, selamectin selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.

Technology Process of Stronghold

There total 8 articles about Stronghold which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C43H62O11 → [3H]-Selamectin (165108-07-6,220119-17-5)

Guidance literature:

With hydroxylamine hydrochloride; In water; isopropyl alcohol; at 40 ℃; for 7h;

Reference yield:

C50H72O14 → [3H]-Selamectin (165108-07-6,220119-17-5)

Guidance literature:

With hydroxylamine hydrochloride; In 1,4-dioxane; methanol; water; at 40 ℃; for 4h; Solvent; Temperature; Industrial scale;

Reference yield:

C43H62O11 → C43H63NO11 (165108-07-6,220119-17-5)

Guidance literature:

With hydroxylamine hydrochloride; In water; isopropyl alcohol; at 10 - 30 ℃; Temperature; Inert atmosphere; Large scale;

upstream raw materials:

doramectin

doramectin

C₅₀H₇₆O₁₄

Refernces

• 1、 -. "Preparation method of high-purity celecampin". . . Retrieved 2019/07/25.
• 2、 -. "NEW SYNTHESIS PROCESS OF ANTIPARASITIC DRUG SELAMECTIN". . . Retrieved 2015/02/25.