Technology Process of 1-(2-hydroxybenzyl)-1-<3-(N,N-dimethylamino)propoxy>cycloheptane
There total 4 articles about 1-(2-hydroxybenzyl)-1-<3-(N,N-dimethylamino)propoxy>cycloheptane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
Ambient temperature;
DOI:10.1248/cpb.31.1267
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / thionyl chloride / benzene / 2.5 h / Heating
2: 1.) Mg, ethyl iodide, iodine / 1.) THF, 45 min, 0-10 deg C; 2.) THF, 20 min 10-15 deg C, then 30 min reflux
3: 22 percent / sodium hydride / toluene / 6 h / Heating
4: 80 percent / hydrogen / 5 percent palladium on charcoal / ethanol / Ambient temperature
With
thionyl chloride; hydrogen; iodine; sodium hydride; magnesium; ethyl iodide;
palladium on activated charcoal;
In
ethanol; toluene; benzene;
DOI:10.1248/cpb.31.1267
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 22 percent / sodium hydride / toluene / 6 h / Heating
2: 80 percent / hydrogen / 5 percent palladium on charcoal / ethanol / Ambient temperature
With
hydrogen; sodium hydride;
palladium on activated charcoal;
In
ethanol; toluene;
DOI:10.1248/cpb.31.1267
