n-Ethyl-2-hydroxybenzamide

Base Information

• Chemical Name: n-Ethyl-2-hydroxybenzamide
• CAS No.: 4611-42-1
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• European Community (EC) Number: 873-657-1
• DSSTox Substance ID: DTXSID70196727
• Nikkaji Number: J48.302H
• Wikidata: Q83069741
• Mol file: 4611-42-1.mol

Synonyms:n-ethyl-2-hydroxybenzamide;4611-42-1;N-Ethylsalicylamide;Salicylethylamide;Salicylamide, N-ethyl-;BRN 2829309;Benzamide, N-ethyl-2-hydroxy-;ethyl salicyl-amide;SCHEMBL1797745;DTXSID70196727;MFCD01684552;AKOS000207592;AM803933;AS-58874;LS-144160;CS-0037834;EN300-1263642;Z252387016

Chemical Property of n-Ethyl-2-hydroxybenzamide

Chemical Property:

• Vapor Pressure: 3.5E-05mmHg at 25°C
• Boiling Point: 343.6°Cat760mmHg
• Flash Point: 161.6°C
• PSA: 52.82000
• Density: 1.141g/cm³
• LogP: 1.71670
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

97% ^*data from raw suppliers

N-Ethyl-2-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC(=O)C1=CC=CC=C1O

Technology Process of n-Ethyl-2-hydroxybenzamide

There total 6 articles about n-Ethyl-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

ethylamine (75-04-7,85404-22-4) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → salicylic acid ethylamide (4611-42-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 0.166667h; Ambient temperature;

Reference yield:

3-ethyl-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione (2038-01-9) → salicylic acid ethylamide (4611-42-1)

Guidance literature:

With sodium hydride; In ethanol; for 4h; Heating;

Reference yield:

phenyl Salicylate (118-55-8) + ethylamine (75-04-7,85404-22-4) → salicylic acid ethylamide (4611-42-1)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 30 ℃; Rate constant; pH=11.58-12.12;

upstream raw materials:

phenyl Salicylate

ethylamine

2-ethylbenzisoxazolium fluoroborate

salicylic acid

Downstream raw materials:

2-(2,3-dihydroxy-propoxy)-benzoic acid ethylamide

3-Ethyl-4-thio-benzo<1.3>oxazin-2,4-dion

3-Ethyl-2-phenyl-2,3-dihydro-benzo[e][1,3,2]oxazaphosphinin-4-one

3-ethyl-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione

Refernces

• 1、 Zaleska,Lis. "An efficient and novel synthesis of 1,3-benzoxazine-2,4-dione and its derivatives". . p. 150 - 151. Retrieved 2007/10/02.
• 2、 Einhorn, J.,Einhorn, C.,Luche, J.-L.. "A CONVENIENT METHOD FOR THE PREPARATION OF N-METHOXYAMIDES". . p. 1105 - 1112. Retrieved 2007/10/02.