Carbinoxamine maleate

Base Information

• Chemical Name: Carbinoxamine maleate
• CAS No.: 3505-38-2
• Deprecated CAS: 121366-99-2
• Molecular Formula: C16H19ClN2O^.C4H4O4
• Molecular Weight: 406.866
• Hs Code.: 2933399090
• European Community (EC) Number: 222-498-0
• NSC Number: 756670,62362
• UNII: 02O55696WH
• DSSTox Substance ID: DTXSID0047828
• Wikidata: Q27114280
• NCI Thesaurus Code: C47432
• RXCUI: 91066
• ChEMBL ID: CHEMBL1200974
• Mol file: 3505-38-2.mol

Synonyms:carbinoxamine;carbinoxamine maleate;Histex CT;Histex I-E;Histex PD

Chemical Property of Carbinoxamine maleate

Chemical Property:

• Appearance/Colour: Off-white solid
• Melting Point: 117-119 °C
• Boiling Point: 579.1 °C at 760 mmHg
• Flash Point: 304 °C
• PSA: 99.96000
• LogP: 3.11440
• Storage Temp.: -20°C Freezer
• Water Solubility.: Completely soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 406.1295495
• Heavy Atom Count: 28
• Complexity: 386

Purity/Quality:

99.9% ^*data from raw suppliers

Carbinoxamine maleate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
• Description: Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine. It also competes with [3H]diltiazem, an L-type calcium channel blocker, for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM). Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM) and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively) by 48% compared with control. Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.
• Uses: antihistaminic
• Therapeutic Function: Antihistaminic

Technology Process of Carbinoxamine maleate

There total 1 articles about Carbinoxamine maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ carbinoxamine maleate (3505-38-2)

Guidance literature:

Refernces