(R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline

Base Information

• Chemical Name: (R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline
• CAS No.: 1287795-39-4
• Molecular Formula: C₁₄H₁₃ClN₂
• Molecular Weight: 244.724
• Mol file: 1287795-39-4.mol

Synonyms:(R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline

Chemical Property of (R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline

There total 2 articles about (R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(3-chlorophenyl)quinoxaline (27993-83-5) → (R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline (1287795-39-4)

Guidance literature:

With diiodo(p-cymene)ruthenium(II) dimer; (S)-3,3'-bis(9-anthracenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate; hydrogen; In benzene; at 20 ℃; for 48h; under 31029.7 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1021/ja200723n

Reference yield: 75.0%

C8H7ClO3 (177288-16-3) + 1,2-diamino-benzene (95-54-5) → (R)-2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinoxaline (1287795-39-4)

Guidance literature:

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogenphosphate; Hantzsch ester; In chloroform; at 35 ℃; for 24h; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/adsc.201300576

upstream raw materials:

2-(3-chlorophenyl)quinoxaline

C₈H₇ClO₃

1,2-diamino-benzene

Refernces

• 1、 Chen, Qing-An,Gao, Kai,Duan, Ying,Ye, Zhi-Shi,Shi, Lei,Yang, Yan,Zhou, Yong-Gui. "Dihydrophenanthridine: A new and easily regenerable NAD(P)H model for biomimetic asymmetric hydrogenation". supporting information; experimental part. p. 2442 - 2448. Retrieved 2012/03/10.