3'-bromomethylpropiophenone

Base Information

• Chemical Name: 3'-bromomethylpropiophenone
• CAS No.: 216873-64-2
• Molecular Formula: C₁₀H₁₁BrO
• Molecular Weight: 227.101
• Mol file: 216873-64-2.mol

Synonyms:3'-bromomethylpropiophenone

Chemical Property of 3'-bromomethylpropiophenone

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3'-bromomethylpropiophenone

There total 1 articles about 3'-bromomethylpropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methylbenzonitrile (620-22-4) → 3'-bromomethylpropiophenone (216873-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide / tetrahydrofuran / 22 h / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

With N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane; 1: |Grignard Reaction;

DOI:10.1039/c3cc49068h

Reference yield: 26.7%

3'-bromomethylpropiophenone (216873-64-2) + sodium hydrogencarbonate (144-55-8) + trans-N-(6,6-dimethylhept-2-en-4-ynyl)-methylamine (83554-69-2) → Trans-3'-[N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methylaminomethyl]propiophenone (216871-10-2)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide;

Reference yield:

3'-bromomethylpropiophenone (216873-64-2) → 2-amino-3-(3-propionylphenyl)propanoic acid hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: potassium iodide; potassium carbonate / acetonitrile / Reflux

2: hydrogenchloride / Reflux

With hydrogenchloride; potassium carbonate; potassium iodide; In acetonitrile;

DOI:10.1039/c3cc49068h

upstream raw materials:

3-Methylbenzonitrile

Downstream raw materials:

Trans-3'-[N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methylaminomethyl]propiophenone

diethyl 2-acetamido-2-(3-propionylbenzyl)malonate

Refernces