Oxytetracycline hydrochloride

Base Information

• Chemical Name: Oxytetracycline hydrochloride
• CAS No.: 2058-46-0
• Molecular Formula: C22H25ClN2O9
• Molecular Weight: 496.901
• Hs Code.: 29413000
• Mol file: 2058-46-0.mol

Synonyms:2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5a,5aa,6b,12aa)]-;1-Dimethylamino-1,4,6,11,12,13,14,18-octahydro-2,5,7,11,12,14-hexahydroxy-4,6-dioxo-11-methylnaphthacene-3-carbonamidehydrochloride;5-Hydroxytetracycline hydrochloride;5-Hydroxytetracyclinemonohydrochloride;Alamycin;Aquacycline;Duphacycline;Engemycin;Gynamousse;Mepatar;Oxy WS;Oxy-Dumocyclin;Oxybiotic;Oxycyclin;Oxypan;Oxytet;Oxytetrin;TM 5;Terraject;Terramycin hydrochloride;Tetra-Tabilinen;Tetran hydrochloride;Toxinal;Vetilmicin;

Chemical Property of Oxytetracycline hydrochloride

Chemical Property:

• Appearance/Colour: Yellow crystalline solid
• Vapor Pressure: 2.17E-30mmHg at 25°C
• Melting Point: 180 °C
• Boiling Point: 845.6 °C at 760 mmHg
• Flash Point: 465.2 °C
• PSA: 201.85000
• Density: ==
• LogP: 0.25870
• Storage Temp.: 0-6°C
• Sensitive.: Light Sensitive
• Solubility.: Soluble in ethanol
• Water Solubility.: >100 g/L

Purity/Quality:

99% ^*data from raw suppliers

Oxytetracycline hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 63-36-36/37/38
• Safety Statements: 36/37/39-26-36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells and antibiotic susceptibilities of Mycoplasma bovis isolates.
• Uses: Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome- lysosome (P-L) fusion in P388D1 cells1 and antibiotic susceptibilities of Mycoplasma bovis isolates.
• Therapeutic Function: Antibiotic

Technology Process of Oxytetracycline hydrochloride

There total 2 articles about Oxytetracycline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

oxytetracycline 5-sulphosalicylate (61068-97-1) → oxytetracycline hydrochloride (2058-46-0)

Guidance literature:

With calcium chloride; In methanol; at 60 ℃;

Reference yield:

→ oxytetracycline hydrochloride (2058-46-0)

Guidance literature:

Reference yield:

oxytetracycline hydrochloride (2058-46-0) → oxamic acid (471-47-6) + oxalic acid (144-62-7,97993-78-7) + acetic anhydride (108-24-7) + maleic acid (110-16-7,26099-09-2) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2)

Guidance literature:

With water; sodium sulfate; pH=7; Electrochemical reaction;

DOI:10.4067/S0717-97072014000200024

upstream raw materials:

oxytetracycline 5-sulphosalicylate

Downstream raw materials:

oxamic acid

oxalic acid

acetic anhydride

maleic acid

Refernces

• 1、 Issar, M. M.,Mahadevan, P. R.. "Interaction between Oxytetracycline Sulphosalicylate and Calcium Chloride". . p. 257 - 258. Retrieved 2007/10/02.