2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate

Base Information

• Chemical Name: 2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate
• CAS No.: 308806-04-4
• Molecular Formula: C₁₅H₁₆N₂O₂
• Molecular Weight: 256.304
• Mol file: 308806-04-4.mol

Synonyms:2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate

Chemical Property of 2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate

There total 2 articles about 2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

methyl cyanoformate (17640-15-2) + 2-phenyl-2-(pyrid-3-yl)ethylamine (199286-24-3) → 2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate (308806-04-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/jhet.5570370417

Reference yield:

α-phenyl-3-pyridineacetonitrile (5005-40-3) → 2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate (308806-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / NaBH₄; I₂ / tetrahydrofuran / 3 h / Heating

2: 50 percent / Et₃N / CH₂Cl₂ / 24 h / 20 °C

With sodium tetrahydroborate; iodine; triethylamine; In tetrahydrofuran; dichloromethane; 1: Reduction / 2: Acylation;

DOI:10.1002/jhet.5570370417

upstream raw materials:

methyl cyanoformate

2-phenyl-2-(pyrid-3-yl)ethylamine

α-phenyl-3-pyridineacetonitrile

Refernces