2,3-Dimethylpiperidine

Base Information

• Chemical Name: 2,3-Dimethylpiperidine
• CAS No.: 5347-68-2
• Molecular Formula: C7H15 N
• Molecular Weight: 113.2
• Hs Code.: 2933399090
• European Community (EC) Number: 824-804-3
• NSC Number: 3818
• DSSTox Substance ID: DTXSID10968187
• Nikkaji Number: J512.432H
• Mol file: 5347-68-2.mol

Synonyms:2,3-Dimethylpiperidine;5347-68-2;2,3-Lupetidine;2,3-Dimethyl-piperidine;Nonafin (free base);Piperidine, 2,3-dimethyl-;UNII-8936173PTJ;NSC3818;NSC 3818;SCHEMBL26055;DTXSID10968187;DRLFSUDDXLQHJT-UHFFFAOYSA-N;NSC-3818;MFCD03425894;STK664104;AKOS000302979;AKOS016343891;8936173PTJ;AM81284;SB43053;BS-12922;BB 0253825;CS-0252665;FT-0600909;FT-0652142;EN300-61154;E80402;A829619;Z959345762

Chemical Property of 2,3-Dimethylpiperidine

Chemical Property:

• Vapor Pressure: 6.17mmHg at 25°C
• Boiling Point: 140.3°Cat760mmHg
• PKA: 10.67±0.10(Predicted)
• Flash Point: 28°C
• PSA: 12.03000
• Density: 0.794g/cm³
• LogP: 1.72320
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 113.120449483
• Heavy Atom Count: 8
• Complexity: 70.8

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dimethylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCCNC1C
• Uses: 2,3-Dimethylpiperidine is involved in the synthesis of novel 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid amide compounds.

Technology Process of 2,3-Dimethylpiperidine

There total 8 articles about 2,3-Dimethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,3-Lutidine (583-61-9) → cis-2,3-dimethylpiperidine (5347-68-2,23513-31-7,23513-39-5)

Guidance literature:

With pyridine; H₂SiEt₂; tris(pentafluorophenyl)borate; hydrogen; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In toluene; at 100 ℃; for 24h; under 30003 Torr; Autoclave;

DOI:10.1021/acscatal.1c02876

Reference yield:

2,3-Lutidine (583-61-9) → 2,3-dimethylpiperidine (5347-68-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 20 ℃; under 1551.49 - 3102.97 Torr;

DOI:10.1039/b209165h

Reference yield:

→ 2,3-dimethylpiperidine (5347-68-2)

Guidance literature:

With sodium; butan-1-ol;

upstream raw materials:

5,6-dimethyl-1,2,3,4-tetrahydro-pyridine

4-methyl-5-oxo-hexanenitrile

hydrogenchloride

2,3-Lutidine

Downstream raw materials:

N-(4-methylphenyl)-4-[(2,3-methyl-1-piperidinyl)carbonyl]-1,3-thiazol-2-amine

2,2-dichloro-1-(4-ethoxyphenyl)cyclopropanyl-2,3-dimethylpiperidin-1-yl ketone

Refernces

• 1、 -. "NOVEL SPIRO IMIDAZOLONE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE". Page/Page column 160. . Retrieved 2011/10/13.