Technology Process of 3-isobutyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]aniline
There total 2 articles about 3-isobutyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium dithionite; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate;
In
tert-butyl methyl ether; water;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; sodium carbonate / acetic acid butyl ester / 10 h / 140 °C / Autoclave
2: sodium hypophosphite monohydrate; palladium on activated charcoal; sodium carbonate / acetic acid butyl ester; water / 3 h / Reflux
3: tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; sodium dithionite / water; tert-butyl methyl ether / 20 °C
With
sodium dithionite; sodium hypophosphite monohydrate; palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; sodium hydrogencarbonate; sodium carbonate; tri tert-butylphosphoniumtetrafluoroborate;
In
tert-butyl methyl ether; acetic acid butyl ester; water;
- Guidance literature:
-
3-isobutyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]aniline;
With
sodium tetrahydroborate;
In
dimethyl sulfoxide;
at 60 ℃;
for 3h;
With
water; acetic acid;
In
dimethyl sulfoxide;
at 0 ℃;
