Chemical Property of Rhodotoxin
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Chemical Property:
- Vapor Pressure:2.34E-14mmHg at 25°C
- Melting Point:258-260oC
- Refractive Index:1.5300 (estimate)
- Boiling Point:549.3°Cat760mmHg
- PKA:13.72±0.70(Predicted)
- Flash Point:184.3°C
- PSA:127.45000
- Density:1.32g/cm3
- LogP:0.73910
- XLogP3:0.8
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:2
- Exact Mass:412.24610348
- Heavy Atom Count:29
- Complexity:724
- Purity/Quality:
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99%, *data from raw suppliers
GRAYANOTOXIN I 95.00% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Chemical Classes:Biological Agents -> Plant Toxins
- Canonical SMILES:CC(=O)OC1C2CCC3C1(CC(C4(C(C3(C)O)CC(C4(C)C)O)O)O)CC2(C)O
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Description
Fructus Rhododendri (ba li ma) is the dried fruit of Rhododendron molle (Bl.)
G. Don (yánɡ zhí zhú), mainly distributed in the Jiangsu, Hubei, and Jiangxi
Provinces of China .“Compendium of Materia Medica” recorded that Rhododendron molle (Bl.)
G. Don (yánɡ zhí zhú) can be used to treat waist pain, arm pain, and poisoning. It is
effective at lowering blood pressure and slowing the heart rate, but a large dosage
can cause death . Rhomotoxin’s formulations include injection and tablet. Side
effects include a burning sensation, numbness, dizziness, dry mouth, nausea, vomiting,
vertigo, chest tightness, slow heartbeat, and low blood pressure. In addition,
pregnant women should use it with caution.
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Physical properties
Appearance: white crystalline or powder. Solubility: soluble in water, acetone, and
chloroform, almost insoluble in diethyl ether or petroleum ether. Melting point:
265–268 °C. Specific optical rotation: ?50 to ?60°.
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Clinical Use
Rhomotoxin acts as an antihypertensive drug, and it is able to lower the blood pressure
in patients with severe hypertension. Its pharmacological effects are related to
parasympathetic function. Large-dosage-induced low blood pressure can be restored
with ephedrine. Its antihypertensive effect lasts for 0.5–1 h. If blood pressure has
not dropped to a satisfactory level, rhomotoxin must not have been added because
an excessive drop in blood pressure would lead to shock. Oral administration with
aluminum hydroxide can reduce rhomotoxin-induced stomach discomfort.
Intramuscular injection can also cause local pain. In addition, procaine reduces its
antihypertensive effect. Secondary hypertension and malignant hypertension
patients should use it with caution, critical and dying patients should be disabled
(including, for example, severe heart failure, cardiomyopathy, atrioventricular
block, and severe ventricular arrhythmias).