Multi-step reaction with 10 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 120 h / 20 °C / Inert atmosphere
2.1: potassium carbonate / ethanol / 2 h / 90 °C / Inert atmosphere
3.1: acetic acid; ammonium acetate / 2 h / 130 °C / Inert atmosphere
4.1: acetic acid; nitric acid / 6 h / 25 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol; water / 6 h / 20 °C
6.1: potassium tert-butylate / dimethyl sulfoxide / 13 h / 150 °C
7.1: methanol; sodium hydroxide / 3 h / 70 °C
8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
9.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
9.2: 2.17 h / 0 - 20 °C
10.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
With
methanol; 1,2,3-Benzotriazole; thionyl chloride; palladium 10% on activated carbon; potassium tert-butylate; ammonium acetate; hydrogen; nitric acid; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide;
In
methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;