Technology Process of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one
There total 14 articles about 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane;
at 125 ℃;
for 2h;
Microwave irradiation;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: silver(l) oxide / toluene / 20 h / 110 °C
2.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C
3.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C
4.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere
5.1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere
5.2: 0.17 h / 0 °C / Inert atmosphere
6.1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / 1,4-dioxane / 2 h / 125 °C / Microwave irradiation; Inert atmosphere
With
methanol; sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; potassium tert-butylate; diisobutylaluminium hydride; silver(l) oxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C
2.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C
3.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere
4.1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere
4.2: 0.17 h / 0 °C / Inert atmosphere
5.1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / 1,4-dioxane / 2 h / 125 °C / Microwave irradiation; Inert atmosphere
With
methanol; sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; potassium tert-butylate; diisobutylaluminium hydride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;