Technology Process of 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5-chloro-indan-2-carboxylic acid
There total 8 articles about 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5-chloro-indan-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5-chloro-indan-2-carboxylic acid ethyl ester;
With
potassium hydroxide; ethanol; water;
at 20 ℃;
With
hydrogenchloride; water;
pH=2;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / potassium iodide / N,N-dimethyl-formamide / 96 h / 43 °C
2.1: methanol; lithium hydroxide; water / 1,4-dioxane / 18 h
2.2: pH 2
3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C
4.1: potassium hydroxide; ethanol; water / 20 °C
4.2: pH 2
With
methanol; potassium hydroxide; lithium hydroxide; ethanol; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
potassium iodide;
In
1,4-dioxane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
2.1: hydrogen bromide / water / 4.5 h / 137 °C
3.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 80 °C
4.1: hydrogenchloride; water / ethanol / 24 h / 20 °C
4.2: pH 9
5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C
6.1: potassium hydroxide; ethanol; water / 20 °C
6.2: pH 2
With
hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; ethanol; water; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;