3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone

Base Information

• Chemical Name: 3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone
• CAS No.: 77801-57-1
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 77801-57-1.mol

Synonyms:3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone

Chemical Property of 3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone

There total 7 articles about 3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 1-bromo-4-methoxy-benzene (104-92-7) → 1-methyl-3-(p-anisyl)-2-pyrrolidinone (107770-12-7) + 3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone (77801-57-1)

Guidance literature:

With lithium cyclohexylisopropylamide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -78 deg C, 45 min, 2.) THF, RT, 12 h;

DOI:10.1021/jo00386a045

Reference yield:

C14H17NO4 → 3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone (77801-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 0.75 h / 0 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 0.33 h / Inert atmosphere

3.1: hydrogenchloride / toluene; water / 2 h / Reflux; Inert atmosphere

With hydrogenchloride; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; water; toluene; mineral oil;

DOI:10.1021/jacs.1c01100

Reference yield:

C15H19NO4 → 3-(3-methoxyphenyl)-1-methyl-2-pyrrolidone (77801-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 0.33 h / Inert atmosphere

2: hydrogenchloride / toluene; water / 2 h / Reflux; Inert atmosphere

With hydrogenchloride; water; sodium hydroxide; In ethanol; water; toluene;

DOI:10.1021/jacs.1c01100

upstream raw materials:

1-methyl-pyrrolidin-2-one

1-bromo-4-methoxy-benzene

2-(3-methoxyphenyl)malonic acid diethyl ester

Refernces

• 1、 Dotson, Jordan J.,Liepuoniute, Ieva,Bachman, J. Logan,Hipwell, Vince M.,Khan, Saeed I.,Houk,Garg, Neil K.,Garcia-Garibay, Miguel A.. "Taming Radical Pairs in the Crystalline Solid State: Discovery and Total Synthesis of Psychotriadine". . p. 4043 - 4054. Retrieved 2021/04/06.