(Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone

Base Information

• Chemical Name: (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone
• CAS No.: 86010-35-7
• Molecular Formula: C₁₇H₁₁NO₃S
• Molecular Weight: 309.345
• Mol file: 86010-35-7.mol

Synonyms:(Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone

Chemical Property of (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone

There total 4 articles about (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-Nitrobenzothiophene-2-carboxaldehyde (4688-16-8) + acetophenone (98-86-2) → (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone (86010-35-7)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1002/jhet.5570200128

Reference yield:

(5-nitrobenzo[b]thiophen-2-yl)methanol (4688-15-7) → (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone (86010-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / t-butyl chromate / 2-methyl-propan-2-ol

2: 75 percent / NaOH / ethanol

With sodium hydroxide; t-butyl chromate; In ethanol; tert-butyl alcohol;

DOI:10.1002/jhet.5570200128

Reference yield:

5-nitrobenzo[b]thiophene-2-carboxylic acid (6345-55-7) → (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone (86010-35-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 14.9 g / thionyl chloride, sodium carbonate / toluene / Heating

2: 1.98 g / sodium borohydride / dioxane / 1) reflux, 5 min; 2) RT, 1 h

3: 96 percent / t-butyl chromate / 2-methyl-propan-2-ol

4: 75 percent / NaOH / ethanol

With sodium hydroxide; sodium tetrahydroborate; thionyl chloride; t-butyl chromate; sodium carbonate; In 1,4-dioxane; ethanol; toluene; tert-butyl alcohol;

DOI:10.1002/jhet.5570200128

upstream raw materials:

5-Nitrobenzothiophene-2-carboxaldehyde

acetophenone

(5-nitrobenzo[b]thiophen-2-yl)methanol

5-nitrobenzo[b]thiophene-2-carboxylic acid

Downstream raw materials:

2-amino-3-cyano-4-(5-nitrobenzothienyl)-6-phenylpyridine

3-cyano-4-(5-nitrobenzothienyl)-6-phenylpyridin-2-one

Refernces