Technology Process of 1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one
There total 4 articles about 1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-10a-[4-(pyrrolidin-1-yl)phenyl]-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
pyrrolidine; 10a-(4-bromophenyl)-2,3,10,10a-tetrahydro-1H,5H-imidazo[1,2-a]pyrrolo[1,2-d]pyrazin-5-one;
With
caesium carbonate;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
at 150 - 160 ℃;
for 0.583333h;
Microwave irradiation;
3-methyl-1,2-oxazole-4-carboxylic acid chloride;
With
pyridine;
at 20 ℃;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C
2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.58 h / 150 - 160 °C / Microwave irradiation
2.2: 20 °C / Cooling with ice
With
oxalyl dichloride; caesium carbonate;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide;
In
dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.33 h / 20 °C
1.2: 2.25 h / 0 - 20 °C
2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 17 h / 20 °C
2.2: pH 1
3.1: xylenes / 1 h / Reflux
4.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.58 h / 150 - 160 °C / Microwave irradiation
4.2: 20 °C / Cooling with ice
With
lithium hydroxide monohydrate; potassium tert-butylate; water; caesium carbonate;
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene; xylenes;