3-chlorophenoxyacetic acid hydrazide

Base Information

• Chemical Name: 3-chlorophenoxyacetic acid hydrazide
• CAS No.: 52094-93-6
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.625
• Mol file: 52094-93-6.mol

Synonyms:3-chlorophenoxyacetic acid hydrazide

Chemical Property of 3-chlorophenoxyacetic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chlorophenoxyacetic acid hydrazide

There total 2 articles about 3-chlorophenoxyacetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl (3-chlorophenoxy)acetate (52094-98-1) → 3-chlorophenoxyacetic acid hydrazide (52094-93-6)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2013.08.027

Reference yield:

3-monochlorophenol (108-43-0) → 3-chlorophenoxyacetic acid hydrazide (52094-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 8 h / Reflux

2: hydrazine hydrate / methanol / 1 h / 20 °C

With potassium carbonate; hydrazine hydrate; In methanol; acetone;

DOI:10.1016/j.bmc.2010.11.034

Reference yield: 91.0%

3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride (943982-60-3) + 3-chlorophenoxyacetic acid hydrazide (52094-93-6) → N'-(2-(3-chlorophenoxy)acetyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbohydrazide

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1002/jhet.3505

upstream raw materials:

3-monochlorophenol

ethyl (3-chlorophenoxy)acetate

Downstream raw materials:

diethyl [2-(3-chlorophenoxymethyl)-9-methylsulfanyl-7H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-d]pyrimidin-7-yl](4-fluorophenyl)methylphosphonate

2-amino-5-m-chlorophenoxymethyl-1,3,4-thiadiazole

C₁₃H₁₀ClN₃O₂S

2-{[(3-chlorophenyl)oxy]acetyl}hydrazinecarbothioamide

Refernces

• 1、 Wang, Wei,Zheng, Xiao-Rui,Huang, Xiao-Ying,Mao, Ming-Zhen,Liu, Kang-Yun,Xue, Chao,Wang, Lie-Ping,Ning, Bin-Ke. "Synthesis and Insecticidal Evaluation of Novel N-pyridylpyrazole Derivatives Containing Diacylhydrazine/1,3,4-Oxadiazole Moieties". . p. 1330 - 1336. Retrieved 2019/01/30.
• 2、 Maingot, Lucie,Elbakali, Jamal,Dumont, Julie,Bosc, Damien,Cousaert, Nicolas,Urban, Agathe,Deglane, Gaelle,Villoutreix, Bruno,Nagase, Hideaki,Sperandio, Olivier,Leroux, Florence,Deprez, Benoit,Deprez-Poulain, Rebecca. "Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group". . p. 244 - 261. Retrieved 2013/10/01.