Technology Process of 1-Phenyl-<1,2-13C2>cyclohexancarbonitril
There total 5 articles about 1-Phenyl-<1,2-13C2>cyclohexancarbonitril which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 93 percent / BBr3 / petroleum ether / 2 h / Heating
2: 1.) 2.2N BuLi, 2.) NaI / 1.) hexane, THF, 40 deg C, 1h, 2.) hexane, THF, 75 deg C, 15 h
With
n-butyllithium; boron tribromide; sodium iodide;
In
Petroleum ether;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) TsCl, KOH, 2.) LiBr / 1.) r.t., ether, 2.) acetone, 4 h, reflux
2: 93 percent / BBr3 / petroleum ether / 2 h / Heating
3: 1.) 2.2N BuLi, 2.) NaI / 1.) hexane, THF, 40 deg C, 1h, 2.) hexane, THF, 75 deg C, 15 h
With
potassium hydroxide; n-butyllithium; boron tribromide; p-toluenesulfonyl chloride; sodium iodide; lithium bromide;
In
Petroleum ether;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / 0.98M DIBAH / diethyl ether; hexane / 24 h / Ambient temperature
2: 1.) TsCl, KOH, 2.) LiBr / 1.) r.t., ether, 2.) acetone, 4 h, reflux
3: 93 percent / BBr3 / petroleum ether / 2 h / Heating
4: 1.) 2.2N BuLi, 2.) NaI / 1.) hexane, THF, 40 deg C, 1h, 2.) hexane, THF, 75 deg C, 15 h
With
potassium hydroxide; n-butyllithium; boron tribromide; diisobutylaluminium hydride; p-toluenesulfonyl chloride; sodium iodide; lithium bromide;
In
diethyl ether; hexane; Petroleum ether;