2-amino-5-bromobenzoic acid hydrochloride

Base Information

• Chemical Name: 2-amino-5-bromobenzoic acid hydrochloride
• CAS No.: 74189-16-5
• Molecular Formula: C₇H₆BrNO₂*ClH
• Molecular Weight: 252.495
• Mol file: 74189-16-5.mol

Synonyms:2-amino-5-bromobenzoic acid hydrochloride

Chemical Property of 2-amino-5-bromobenzoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-5-bromobenzoic acid hydrochloride

There total 2 articles about 2-amino-5-bromobenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-Bromo-2-aminobenzoic acid (5794-88-7) → 2-amino-5-bromobenzoic acid hydrochloride (74189-16-5)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 24h;

Reference yield: 53.0%

5-Bromo-1H-indole-2,3-dione (87-48-9) → 2-amino-5-bromobenzoic acid hydrochloride (74189-16-5)

Guidance literature:

5-Bromo-1H-indole-2,3-dione; With dihydrogen peroxide; sodium hydroxide; In water; at 50 ℃; for 0.5h;

With hydrogenchloride; In water; pH=Ca. 4;

DOI:10.1021/acs.joc.9b01433

Reference yield: 97.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 2-amino-5-bromobenzoic acid hydrochloride (74189-16-5) → 2-amino-5-bromo-N-methoxy-N-methyl-benzamide (304854-54-4)

Guidance literature:

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.9b01433

upstream raw materials:

5-Bromo-2-aminobenzoic acid

5-Bromo-1H-indole-2,3-dione

Downstream raw materials:

7-bromo-2-phenyl-3-p-tolyl-thiazolo[2,3-b]quinazolin-5-one

7-bromo-3-(4-chloro-phenyl)-2-phenyl-thiazolo[2,3-b]quinazolin-5-one

7-bromo-2,3-diphenyl-thiazolo[2,3-b]quinazolin-5-one

5-Bromo-2-thioureido-benzoic acid

Refernces

• 1、 -. "Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof". Page/Page column 359. . Retrieved 2016/04/26.
• 2、 -. "COMBINATION OF KINASE INHIBITORS AND USES THEREOF". Paragraph 00641. . Retrieved 2014/10/04.