4-(6-ethylbenzothiazol-2-yl)phenylamine

Base Information

• Chemical Name: 4-(6-ethylbenzothiazol-2-yl)phenylamine
• CAS No.: 1237737-87-9
• Molecular Formula: C₁₅H₁₄N₂S
• Molecular Weight: 254.356
• Mol file: 1237737-87-9.mol

Synonyms:4-(6-ethylbenzothiazol-2-yl)phenylamine

Chemical Property of 4-(6-ethylbenzothiazol-2-yl)phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(6-ethylbenzothiazol-2-yl)phenylamine

There total 6 articles about 4-(6-ethylbenzothiazol-2-yl)phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-ethyl-2-(4-nitrophenyl)benzothiazole (1237737-84-6) → 4-(6-ethylbenzothiazol-2-yl)phenylamine (1237737-87-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In dichloromethane; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.04.082

Reference yield: 83.0%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) + 2-amino-5-ethylbenzothiazole (90382-10-8) → 4-(6-ethylbenzothiazol-2-yl)phenylamine (1237737-87-9)

Guidance literature:

With melamine formaldehyde resin supported sulfuric acid; Microwave irradiation;

DOI:10.1134/S1070363215030251

Reference yield:

4-aminoethylbenzene (589-16-2) → 4-(6-ethylbenzothiazol-2-yl)phenylamine (1237737-87-9)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / benzene / Reflux

2: Lawessons reagent / chlorobenzene / 135 °C

3: potassium hexacyanoferrate(III); sodium hydroxide / water / 90 °C

4: hydrogen; palladium 10% on activated carbon / dichloromethane / 25 °C

With Lawessons reagent; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydroxide; potassium hexacyanoferrate(III); In dichloromethane; water; chlorobenzene; benzene;

DOI:10.1039/c6md00034g

upstream raw materials:

6-ethyl-2-(4-nitrophenyl)benzothiazole

4-amino-benzoic acid

2-amino-5-ethylbenzothiazole

4-aminoethylbenzene

Refernces

• 1、 Senadi, Gopal Chandru,Liao, Chieh-Ming,Kuo, Kung-Kai,Lin, Jian-Cheng,Chang, Long-Sen,Wang, Jeh Jeng,Hu, Wan-Ping. "Design, synthesis and antimetastatic evaluation of 1-benzothiazolylphenylbenzotriazoles for photodynamic therapy in oral cancer cells". . p. 1151 - 1158. Retrieved 2016/07/06.