N-(tert-butyloxycarbonyl)-2-fluorobenzylamine

Base Information

• Chemical Name: N-(tert-butyloxycarbonyl)-2-fluorobenzylamine
• CAS No.: 153903-21-0
• Molecular Formula: C₁₂H₁₆FNO₂
• Molecular Weight: 225.263
• Mol file: 153903-21-0.mol

Synonyms:N-(tert-butyloxycarbonyl)-2-fluorobenzylamine

Chemical Property of N-(tert-butyloxycarbonyl)-2-fluorobenzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)-2-fluorobenzylamine

There total 8 articles about N-(tert-butyloxycarbonyl)-2-fluorobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-fluorobenzylamine (89-99-6) → N-(tert-butyloxycarbonyl)-2-fluorobenzylamine (153903-21-0)

Guidance literature:

With triethylamine; In dichloromethane; for 3h;

DOI:10.1016/S0040-4020(01)00159-4

Reference yield: 87.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + carbon dioxide (124-38-9,18923-20-1) + N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-2-fluorobenzylamine (1174761-19-3) → methyl 2-((tert-butoxycarbonyl)amino)-2-(2-fluorophenyl)acetate (709665-72-5) + N-(tert-butyloxycarbonyl)-2-fluorobenzylamine (153903-21-0)

Guidance literature:

carbon dioxide; N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-2-fluorobenzylamine; With toluene-4-sulfonic acid; cesium fluoride; dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane; In N,N-dimethyl-formamide; at 20 ℃; for 3h; under 3750.38 Torr;

diazomethane; In diethyl ether;

DOI:10.1021/ol302952r

Reference yield: 10.0%

C23H21F18NO3 (1228693-10-4) → N-(tert-butyloxycarbonyl)-2-fluorobenzylamine (153903-21-0)

Guidance literature:

With tris(acetonitrile)tricarbonylmolybdenum⁽⁰⁾; In methanol; at 130 ℃; chemoselective reaction; Sonication; Microwave irradiation; Inert atmosphere;

DOI:10.1002/chem.200903178

upstream raw materials:

di-tert-butyl dicarbonate

2-fluorobenzylamine

C₂₃H₂₁F₁₈NO₃

diazomethane

Downstream raw materials:

1-(2-fluorophenyl)-N-methylmethanamine

Refernces

• 1、 Mita, Tsuyoshi,Chen, Jianyang,Sugawara, Masumi,Sato, Yoshihiro. "One-pot synthesis of α-amino acids from CO2 using a bismetal reagent with Si-B bond". . p. 6202 - 6205. Retrieved 2013/02/23.
• 2、 Nielsen, Simon D.,Smith, Garrick,Begtrup, Mikael,Kristensen, Jesper L.. "Synthesis and application of a new fluorous-tagged ammonia equivalent". supporting information; experimental part. p. 4557 - 4566. Retrieved 2010/08/20.