(S)-N-(7-Amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide hydrochloride

Base Information

• Chemical Name: (S)-N-(7-Amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide hydrochloride
• CAS No.: 4272-74-6
• Molecular Formula: C14H21 Cl N2 O3 S . Cl H
• Molecular Weight: 369.3071
• Hs Code.: 29350090
• European Community (EC) Number: 224-266-4,224-199-0
• DSSTox Substance ID: DTXSID3045807
• ChEMBL ID: CHEMBL1256974
• Mol file: 4272-74-6.mol

Synonyms:Chloromethane, Tosyllysyl;Chloromethyl Ketone, Tosyllysine;Chlorotosylamidoaminoheptanone;Ketone, Tosyllysine Chloromethyl;TLCK;Tosyllysine Chloromethyl Ketone;Tosyllysyl Chloromethane

Chemical Property of (S)-N-(7-Amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide hydrochloride

Chemical Property:

• Appearance/Colour: powder
• Vapor Pressure: 1.65E-10mmHg at 25°C
• Melting Point: ~165 °C (dec.)
• Boiling Point: 509.8 °C at 760 mmHg
• Flash Point: 262.1 °C
• PSA: 97.64000
• Density: g/cm³
• LogP: 4.55280
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 368.0728191
• Heavy Atom Count: 22
• Complexity: 414

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(CCCCN)C(=O)CCl.Cl
• Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl.Cl
• Uses: Tosyllysine chloromethylketone (TLCK) is an active site-directed agent that inhibits serine proteinases with trypsin-like activity. TLCK may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes. To prevent proteolytic degradation, TLCK may be used in protein purification protocols. TLCK selectively inactiviates clostripain obtained from C. histolyticum. Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride has been used:in chymotrypsin purification to prevent binding of trypsins to the affinity support by inhibiting them in the crude extractas a protease inhibitor in tissue and cell homogenizationas a trypsin inhibitor to determine the specific protease activity levels