allopregnane-3,20-diol

Base Information

• Chemical Name: allopregnane-3,20-diol
• CAS No.: 4479-11-2
• Molecular Formula: C21H36 O2
• Molecular Weight: 320.516
• Mol file: 4479-11-2.mol

Synonyms:5x-Pregnane-3,20-diol

Chemical Property of allopregnane-3,20-diol

Chemical Property:

• Vapor Pressure: 1.98E-09mmHg at 25°C
• Boiling Point: 435.9°Cat760mmHg
• Flash Point: 191°C
• PSA: 40.46000
• Density: 1.053g/cm³
• LogP: 4.38700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allopregnane-3,20-diol

There total 28 articles about allopregnane-3,20-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

PREGNANOLONE (128-20-1,128-21-2,516-54-1,516-55-2,4243-94-1,4320-08-5,4406-35-3,4406-37-5,4469-03-8,13089-85-5,13089-86-6,14615-01-1,21788-58-9,24557-99-1,25126-79-8,26961-00-2,36027-63-1,39845-99-3,40135-22-6,72691-57-7,81076-02-0,95118-68-6,110350-90-8) → pregnadiol (80-89-7,80-90-0,80-92-2,516-53-0,566-56-3,566-57-4,566-58-5,4406-36-4,4479-11-2,4707-80-6,6251-84-9,25908-35-4,28818-70-4,36027-66-4,38270-91-6,38270-97-2,52746-43-7,55569-11-4,55660-10-1,73745-18-3,98048-13-6,80-91-1)

Guidance literature:

With dimethylsulfide borane complex; (2S)-2-phenylglycinol; In tetrahydrofuran; for 0.4h; Ambient temperature;

Reference yield:

Progesterone (57-83-0) → pregnan-3-ol-20-one + pregnane-3,20-diol (4479-11-2) + 4-pregnen-20α-ol-3-one (15114-79-1) + 14-hydroxy-4-pregnene-3,20-dione (16031-66-6) + dihydroprogesterone (566-65-4) + 11-alpha-hydroxyprogesterone (80-75-1,22847-91-2) + 6alpha-Hydroxyprogesterone (604-20-6)

Guidance literature:

With Hortaea werneckii B-763 at early logarithmic growth phase; In YNB growth medium; N,N-dimethyl-formamide; at 28 ℃; for 24h; Enzymatic reaction;

DOI:10.1016/j.steroids.2008.08.004

Reference yield:

Progesterone (57-83-0) → pregnan-3-ol-20-one + pregnane-3,20-diol (4479-11-2) + 4-pregnen-20α-ol-3-one (15114-79-1) + testosterone (58-22-0) + dihydroprogesterone (566-65-4) + Androstenedione (63-05-8) + testosterone acetate (1045-69-8)

Guidance literature:

With Hortaea werneckii B-763 at late logarithmic and stationary growth phase; In YNB growth medium; N,N-dimethyl-formamide; at 28 ℃; for 24h; Enzymatic reaction;

DOI:10.1016/j.steroids.2008.08.004

upstream raw materials:

Progesterone

pregnanedione

(20R)-20-hydroxy-5β-pregnan-3α-yl acetate

UC₁₀₁₃

Downstream raw materials:

5α.14β.17βH-pregnanediyl-(3β.20α_F)-diacetate

Refernces

• 1、 Jin, Yi,Mesaros, A. Clementina,Blair, Ian A.,Penning, Trevor M.. "Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: Role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway". supporting information; experimental part. p. 53 - 61. Retrieved 2012/06/15.
• 2、 Goendoes, Gyoergy,Dombi, Gyoergy,Orr, James C.. "A New Chiral Director for the Highly Diastereoselective Borane Reduction of Steroid-20-ones". . p. 1055 - 1060. Retrieved 2007/10/03.